Dissect the precise mechanisms behind endocannabinoid signalling in hypothalamic feeding centres.
funded by DFG-SFB 1052/A07
Endocannabinoids are lipid messengers within the brain that generally transmit the same biological effects via cannabinoid receptor type 1 (CB1) when compared to well-known exogenous cannabinoids, such as THC. Moreover, endocannabinoids are able to induce physiological and pathological effects independently from CB1 activation. Cannabinoids were generally addressed as important metabolic messengers within the body, however the precise mechanisms behind endocannabinoid signalling in central hypothalamic feeding centers is not well investigated. Thus, our research will focus on novel mechanistic insights on how endocannabinoids in the hypothalamic arcuate nucleus will contribute to orchestration of whole-body energy homeostasis. In this context, preliminary work to our project demonstrated that endocannabinoids are present in the arcuate nucleus and thus might affect POMC and AgRP/NPY neurons (see Figure 1).